Functional NMR
Human skeletal muscle: multi-parametric functional NMR (mpf-NMR) on 4T
- Non invasive NMR methodologies in vivo
- Integrated measurements:
Muscle appearance ← NMRI
Resting muscle energetic status ← 31P NMRS
Muscle energy production ← dynamic 31P NMRS
Muscle perfusion ← arterial spin labeled (ASL) NMRI
Blood oxygen level index ← BOLD NMRI
Muscle oxygen uptake ← deoxymyoglobin (dMb) 1H NMRS
- Functional evaluation of muscle during exercise: perfusion, oxygen transport and consumption and energy metabolism
Every 1.5s, simultaneous acquisitions of:
- Clinical applications : glycogenosis with exercise intolerance (GSD V), diabetes type
II, glycogen-storage disease type III…
Advanced methodological developments dedicated to functional NMR of skeletal muscle in small animals
Update: March 2010
